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Anthony Bogaert at Brock University, Canada, and his team think that some women who are pregnant with boys develop antibodies that target a protein made by the Y chromosome. Our immune systems make antibodies to recognise foreign molecules, which have the potential to be from dangerous bacteria. But pregnant women sometimes also produce antibodies against fetal molecules — for example, if their fetus has a different blood group. The team collected blood from women, and screened it for antibodies to a particular brain protein that is only made in males. They thought this would be a good candidate, because it plays an important role in how neurons communicate with each other, and because it is produced on the surface of brain cells, making it relatively easy for antibodies to find and detect it.
Being a parent is an exercise in expecting the unexpected. The best example—to date, at least—happened on a regular weekday evening. My husband, my son and I were sitting around the dining room table and, like usual, I was trying my hardest to draw out some juicy details about their day.